The Argentina international has continually been linked with a move away from the Liga champions, and Paris Saint-Germain star Javier Pastore revealed earlier this weekend that Higuain has been in touch with him over a potential move.
Nevertheless, Mourinho has stressed that the 24-year-old is not for sale at any price.
"Higuain is staying here. He will stay at Madrid because I don't want him to go. He has an excellent contract here that runs for many more years," Mourinho stated to ABC.
"And Madrid have no intention to sell either. Even if clubs offer 40, 50 or €60 million, we will not sell him. My two strikers for next season will be [Karim] Benzema and Higuain."
Higuain has netted 22 goals in 34 Primera Division appearances this season.